Our ultimate goal is to better understand the balance of forces that determine the vast array of observed crystal structures. This knowledge can be used to build desired nanoscale architectures. Students who work in the Koplitz lab learn to use a variety of programs to visualize molecules and crystals. They also use differential scanning calorimetry to precisely characterize melting points and other thermodynamic properties of isomeric pyridinium and anilinium salts that they have made themselves. Since 2003, the Koplitz group has published thirteen new crystal structures. Students frequently present their research results at national and regional scientific conferences and over the past decade, ten students have co-authored peer-reviewed publications.